Investigating The Effect of Boron Oxide Substitution in the 6P55 Glass Composition for Designing an Appropriate Bioactive Coating for Ti6Al4V: Melt- Quench Synthesis and Computational, Thermal and Biological Analysis

While considering their application in orthopedics and dentistry, Ti6Al4V metallic implants face problems of poor integration with the surrounding tissues over time. Bioactive coatings can help to solve these issues by strengthening the bond between the tissues and the implant, which can also temporarily increase the lifespan of the implant. This research examines the modification of 6P55 bioactive glass, which shows promise as a coating for Ti6Al4V implants, in order to address these issues. Specifically, the modification of 6P55 with controlled substitution of boron oxide (B₂O₃) will be determined. As an intermediate glass former, boron will be added to the glass system (SiO₂₍₅₄.₅₋ₓ₎–B₂O₃₍ₓ₎–P₂O₅–MgO–CaO–Na₂O–K₂O, with x = 0, 5, 10, 15

mol%). This study will use a melt-quench method to synthesize the materials, along with classical molecular dynamics (MD) simulations to examine the structural changes at the atomic level. Subsequently, a series of thermal and biological tests will be completed in order to evaluate the effects of boron on the glass structure and bioactivity. The goal of this study is to create a bioactive coating that enhances tissue integration of the implant, thereby improving the performance of the coated Ti6Al4V implants.

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