Advanced vitro cardiac models drug is a M.Tech project topic for Biotechnology & Biomedical Engineering. It gives students a clear starting point for research, implementation planning, and documentation.
Advanced vitro cardiac models drug Project Details
| Abstract |
The proposed M.Tech project aims to study the development and use of textit{in vitro} cardiac models as better alternatives than both 2D cultures and animal models for drug testing. The project aims to study biomimetic models that reproduce the human myocardial structure and function as a complete model. These models include engineered 3D architectures, chambered ventricular constructs, self-organizing cardiac organoids, and microphysiological systems. These models are promising drug development tools (DDTs) for the safety, efficacy, and cardiotoxicity assessments, with far greater predictive capabilities than those offered by standard assessments. textit{In vitro} systems with advanced preclinical research design most effectively mimic the physiological environment of the human body. Recent advances in
organoid maturation, vascularized engineered cardiac tissues, and chips capable of real-time contractility and electrophysiological stimulation are the basis for this research. Models with integrated immune and vascular systems, potentially with multi-organ systems, facilitate evaluation of drugs in a whole-organism system and enhance disease model development, thus bridging the gap between traditional textit{in vitro} models and dynamic systems.
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| Reference Paper |
Advanced in vitro cardiac models for drug evaluation: integration of organoids, engineered tissues, and microphysiological systems |
| Domain |
Biotechnology & Biomedical Engineering |
| Sub-Domain |
Biomedical Devices / Tissue Engineering / Bioreactor Design |
| PDF Download |
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| Get Help |
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