Opto-Biological Modulation System for the Precision Manufacturing and Evaluation of Myopia-Control Spectacle Lenses

This project looks at how to combine optical design, precise manufacturing, and the eye’s biological response to test lenses that control myopia. Traditional tests usually study optics and biology separately, which can give mixed clinical results. Our method treats the lens and the eye as one “opto‑biological” system. We connect manufacturing details and wide‑field aberration data to models of how the retina processes signals. To do this, we use a difference‑of‑Gaussians (DoG) filter as a computer stand‑in for retinal receptive fields. The DoG filter lets us see how the eye handles spatial contrast and defocus information. By linking lens design features—like peripheral myopic defocus and high‑order aberrations—to the simulated biological

responses, we create clear, quantitative guidelines for improving manufacturing processes. The work also supports the creation of high‑precision freeform machining methods and measurement standards for future ophthalmic lenses. With this framework, engineering students can model, simulate, and evaluate the complex interaction between optics and biology, tying tight manufacturing tolerances to real visual outcomes.

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